Treatment of exercise-associated hyponatremia with hypertonic IV infusion to correct plasma sodium levels is also a standard and accepted use of IV fluid infusions
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Refurbished Alaris Signature 7130 Infusion IV Pump - 0 views
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Refurbished Alaris Signature 7130 Infusion IV Pump The Alaris IVAC Signature Gold 7130 Infusion Pump is a single channel volumetric infusion pump that allows independent programming on both sides. It can be used for general IV infusions, antibiotics, blood infusions, enteral infusions, TPN and hyperalimentation, and lipids. Dual-rate piggyback function and panel lock.
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Refurbished Alaris Signature 7130 Infusion IV Pump - 0 views
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Refurbished Alaris Signature 7130 Infusion IV Pump The Alaris IVAC Signature Gold 7130 Infusion Pump is a single channel volumetric infusion pump that allows independent programming on both sides. It can be used for general IV infusions, antibiotics, blood infusions, enteral infusions, TPN and hyperalimentation, and lipids. Dual-rate piggyback function and panel lock.
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Intravenous Fluid Use in Athletes - 0 views
www.ncbi.nlm.nih.gov/...PMC3435915
IV intravenous fluid nutrition athletes athlete sports medicine sports exercise
shared by Nathan Goodyear on 13 Jan 15
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athletes who present for medical care with hypernatremia who cannot tolerate oral fluids can benefit from IV fluids
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Vaporization of sweat accounts for 80% of heat loss in hot, dry atmospheric conditions. This mechanism of water loss is the major contributor for exercise-associated dehydration
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Pre- and postexercise body weight measurements are the most common means to estimate overall water loss but are condition specific
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In highly trained endurance athletes, plasma volume and sodium serum concentration were preserved despite a 5% body weight loss
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In Ironman triathletes, dehydration to 5% body weight loss did not correlate with occurrence of medical complications
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hydration should begin hours prior to exercise, especially if known deficits are present, and fluids should be consumed at a slow, steady rate, with 5 to 7 mL/kg taken 4 hours prior to exercise
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Sodium concentration did not produce significant changes in the rate of absorption but was primarily dependent on carbohydrate concentration
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IV treatment of severe dehydration (>7% body weight loss), exertional heat illness, nausea, emesis, or diarrhea, and in those who cannot ingest oral fluids for other reasons, is clinically indicated
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A recent survey of the National Football League teams revealed that 75% (24 of 32) of the teams utilized IV infusion of fluids for prehydration in at least some otherwise healthy individuals
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In the National Football League, an average of 1.5 L of normal saline was administered approximately 2.5 hours prior to competition
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after 2 hours of exercise, the rectal temperature was 0.6° higher in the group not receiving IV infusion. Also, stroke volume and cardiac output were 11% to 16% lower in the control group versus the IV infusion group.
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Recent evidence suggests the etiology of EAMC is related to muscle fatigue and neuronal excitability
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there may be a subset of muscle cramping that is associated with a loss of both body fluid and sodium
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elevation of plasma volume by 200 to 300 mL via dextran infusion resulted in 15% increase in stroke volume, 4% increase in VO2 max, and an increase in the exercise time to fatigue
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Neither the tonicity nor mode of hydration resulted in improved speed of rehydration, greater fluid retention, or improved performance
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There are beneficial anecdotal reports of EAMC treatment in elite and professional-level athletes with IV hydration during the course of an event
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Plasma volume was better restored during rehydration with IV fluids at preexercise and 5 minutes of exercise. At 15 minutes, there was no difference between IV and oral rehydration
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More rapid restoration of plasma volume was accomplished in the IV treatment group with no advantages over oral rehydration in physiological strain, heat tolerance, ratings of perceived effort, or thermal sensations
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No difference was found in exercise time to exhaustion. IV and oral rehydration methods were equally effective. Heart rates were statistically higher in the oral rehydration group through 75 minutes of exercise, and there were higher increases in norepinephrine plasma concentrations
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No significant differences between the groups were found for time to recovery, number of days with pain, number of days with stiffness, sleep disturbance, fatigue, rectal temperature, and loss of appetite
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There may be physiological benefits of decreased heart rate and norepinephrine in athletes rehydrated via IV route
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Postexercise blood 1 hour and 24 hours showed no differences in circulating myoglobin or creatine kinase
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this should be reserved for high-level athletes with strong histories of symptoms in well-monitored settings.
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Intravenous Ascorbate as a Tumor Cytotoxic Chemotherapeutic Agent - 0 views
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Ascorbic acid and its salts (AA) are preferentially toxic to tumor cells in vitro (6 — 13) and in vivo
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Increases animal and human resistance to infectious agents by enhancing lymphocyte blastogenesis, enhancing cellular immunity, strengthening the extracellular matrix, and enhancing bactericidal activity of neutrophils and modulation of complement protein
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Strengthens the structural integrity of the extracellular matrix which is responsible for stromal resistance to malignant invasiveness
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In 1977, Bram et al reported preferential AA toxicity for several malignant melanoma cell lines, including four human-derived lines
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Noto et al reported that AA plus vitamin K3 had growth inhibiting action against three human tumor cell lines at non-toxic levels
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The AA begins to reduce cell proliferation in the tumor cell line at the lowest concentration, 1.76 mg/dl, and is completely cytotoxic to the cells at 7.04 mg/dl
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preferential toxicity of AA for tumor cells. >95% toxicity to human endometrial adenocarcinoma and pancreatic tumor cells (ATCC AN3-CA and MIA PaCa-2) occurred at 20 and 30 mg/dl, respectively.
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No toxicity or inhibition was demonstrated in the normal, human skin fibroblasts (ATCC CCD 25SK) even at the highest concentration of 50 mg/dl.
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Cameron and Pauling have published extensive suggestive evidence for prolonged life in terminal cancer patients orally supplemented (with and without initial intravenous AA therapy) with 10 g/day of AA
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the long-term, oral dosage used in those experiments (10 g/day), while substantial and capable of producing immunostimulatory and extracellular matrix modulation effects, was not high enough to achieve plasma concentrations that are generally cytotoxic to tumor cells in culture
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5 — 40 mg/dl of AA is required in vitro to kill 100% of tumor cells within 3 days. The 100% kill levels of 30 mg/dl for the endometrial carcinoma cells and 40 mg/dl for the pancreatic carcinoma cells in Figure 2 are typical
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1 h after beginning his first 8-h infusion of 115 g AA (Merit Pharmaceuticals, Los Angeles, CA), the plasma AA was 3.7 mg/dl and at 5 h was 19 mg/dl. During his fourth 8-h infusion, 8 days later, the 1 h plasma level was 158 mg/dl and 5 h was 185 mg/dl
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plasma levels of over 100 mg/dl have been maintained in 3 patients for more than 5 h using continuous intravenous infusion
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In rare instances of patients with widely disseminated and rapidly proliferating tumors, intravenous AA administration (10 — 45 g/day) precipitated widespread tumor hemorrhage and necrosis, resulting in death
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Although the outcomes were disastrous in these cases, they are similar to the description of tumor-necrosis-factor-induced hemorrhage and necrosis in mice (52) and seem to demonstrate the ability of AA to kill tumor cells in vivo.
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toxic effects of AA on one normal cell line were observed at 58.36 mg/dl and the lack of side effects in patients maintaining >100 mg/dl plasma levels
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Although it is very rare, tumor necrosis, hemorrhage, and subsequent death should be the highest priority concern for the safety of intravenous AA for cancer patients.
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Cathcart (55) who describes no ill effects with doses of up to 200 g/d in patients with various pathological conditions
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following circumstances: renal insufficiency, chronic hemodialysis patients, unusual forms of iron overload, and oxalate stone formers
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Screening for red cell glucose-6-phosphate dehydrogenase deficiency, which can give rise to hemolysis of red blood cells under oxidative stress (57), should also be performed
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any cancer therapy should be started at a low dosage to ensure that tumor hemorrhage does not occur.
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a scorbutic rebound effect can be avoided with oral supplementation. Because of the possibility of a rebound effect, measurement of plasma levels during the periods between infusions should be performed to ensure that no such effect takes place
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Every effort should be made to monitor plasma AA levels when a patient discontinues intravenous AA therapy.
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The Role of Vitamin C in Human Immunity and Its Treatment Potential Against COVID-19: A... - 0 views
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White blood cells, including neutrophils and monocytes, accumulate concentrations of vitamin C up to 100 times greater than that of plasma
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Vitamin C is a crucial component of both the innate (nonspecific) and adaptive (specific) portions of the immune system
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maturation, proliferation, and viability of T cells have all been shown to be upregulated by the presence of normal physiologic concentrations of vitamin C
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vitamin C among healthy young adult males showed a significant increase in serum levels of IgA, IgG, and IgM
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effects of high-dose vitamin C on cytokine levels in cancer patients, finding decreased amounts of the cytokines Interleukin-1 alpha (IL-1 alpha), IL-2, IL-8, and tumor necrosis factor-alpha (TNF-alpha) after high-dose vitamin C infusion
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when vitamin C was supplemented with vitamin E in healthy adults, it increased the production of cytokines IL-1 beta and TNF-alpha
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vitamin C acts to modulate the levels of cytokines to prevent them from fluctuating in either direction
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human leukocytes, neutrophils, in particular, possess the ability to transport the oxidized form of vitamin C across its membrane to use as a defense mechanism against ROS produced during an immune response
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Vitamin C also can recover other endogenous antioxidants in the body such as vitamin E and glutathione, returning them to their active state
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can reduce harmful nitrogen-based compounds such as N-nitrosamines and nitrosamides, both of which are carcinogenic
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subjects taking oral vitamin C supplementation saw a 60% to 90% reduction in oxidative stress compared to a placebo control
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subjects infused with vitamin C alone had a 516% increase in glutathione levels compared to subjects not provided the 500 mg daily supplementation
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Studies have demonstrated that those with low levels of vitamin C are at a significantly higher risk of respiratory infection compared to those with normal levels
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viral cold duration was reduced by about 8% in adults and 13.5% in children using prophylactic daily doses of 200 mg of oral vitamin C
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prophylactically supplementing vitamin C decreases the risk of infection with respiratory viruses such as the common cold
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combined with probiotics, oral vitamin C supplementation showed a 33% decrease in the incidence of respiratory tract infections in preschool-age children [
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high-dose oral supplementation of vitamin C managed to prevent or reduce symptoms if taken before or just after the onset of cold- or flu-like symptoms
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improvements in oxygen saturation and decreased IL-6 levels (a marker of inflammation) in the treatment group compared to the control group
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Patients with COVID-19 will likely also experience depletion in serum levels of vitamin C as a direct result of the upregulation of the immune system to combat the infection
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Colunga et al. suggested that oral vitamin C can be combined with oral Quercetin, an antiviral flavonoid, to improve Quercetin’s ability to block viral membrane fusion of SARS-CoV-2
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It appears vitamin C supplementation by itself does not provide a striking benefit in preventing COVID-19 infection for those without a deficiency
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some evidence to support that prophylactic use of vitamin C helps reduce the severity of respiratory infection symptoms once a subject has already been infected
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other studies were unable to find any definitive improvement concerning therapy with vitamin C
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Fowler et al. aimed to see if a high-dose vitamin C infusion would benefit patients affected by ARDS, but they were unable to conclude that vitamin C infusion, compared to a placebo, could decrease vascular inflammation and damage in ARDS
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in a sample of 67 COVID-19-positive ICU patients, 82% of them displayed plasma vitamin C levels below 0.4 mg/dL
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continuous vitamin C infusion at a rate of 60 mg/kg/day for four days decreased the need for mechanical ventilation and vasopressor use but had no significant effect on overall mortality
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Carr et al. suggested that high-dose IV vitamin C is most effective when treating sepsis as septic patients receiving the normal daily recommendations through diet still showed decreased vitamin C levels
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High-dose IV vitamin C treatment has also been shown by Kakodkar et al. to decrease syndecan-1, an endothelial glycocalyx that contributes to mortality in septic patients
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combined with hydrocortisone and thiamine, septic patients treated with 1.5 g of IV vitamin C every six hours showed a distinct decrease in their SOFA scores and none of the patients treated developed organ failure
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combined with hydrocortisone and thiamine, septic patients treated with 1.5 g of IV vitamin C every six hours showed a distinct decrease in their SOFA scores and none of the patients treated developed organ failure
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treatment of severe sepsis using a high dose (up to 200 mg/kg/day) of IV vitamin C was explored in phase I, a double-blind, randomized, placebo-controlled trial by Fowler et al. [75]. Their findings included a reduction in SOFA scores and decreased vascular injury compared to a placebo control group, all while showing minimal adverse side effects
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Maintaining a daily intake of 75 and 100 mg for men and women, respectively, as recommended by the U.S. Institute of Medicine
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Refurbished Abbott Hospira Plum A+ 3 Triple Channel Infusion IV Pump - 0 views
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Refurbished Abbott Hospira Plum A+ 3 Infusion Pump. The A+3 is a triple channel pump that allows each channel to be programmed and ran individually. Delivery rates in include primary, secondary and concurrent. The A+3 allows for a variety of delivery units including: mL/hr, mcg/kg/min, mcg/min, mcg/kg/hr, cg/hr, mg/min, mg/kg/hr, mg/hr, ng/kg/min, g/hr, mEq/hr, Million units/hr, units/min, units/hr, units/kg/hr, units/kg/min, mmol/min, mmol/hr. *Refurbished *1-Year Warranty
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Refurbished Abbott Hospira Plum A+ 3 Triple Channel Infusion IV Pump - 0 views
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Refurbished Abbott Hospira Plum A+ 3 Infusion Pump. The A+3 is a triple channel pump that allows each channel to be programmed and ran individually. Delivery rates in include primary, secondary and concurrent. The A+3 allows for a variety of delivery units including: mL/hr, mcg/kg/min, mcg/min, mcg/kg/hr, cg/hr, mg/min, mg/kg/hr, mg/hr, ng/kg/min, g/hr, mEq/hr, Million units/hr, units/min, units/hr, units/kg/hr, units/kg/min, mmol/min, mmol/hr. *Refurbished *1-Year Warranty
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Refurbished Abbott Hospira Plum A+ 3 Triple Channel Infusion - nextechclassifieds - 0 views
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Refurbished Abbott Hospira Plum A+ 3 Infusion Pump. The A+3 is a triple channel pump that allows each channel to be programmed and ran individually. Delivery rates in include primary, secondary and concurrent. The A+3 allows for a variety of delivery units including: mL/hr, mcg/kg/min, mcg/min, mcg/kg/hr, cg/hr, mg/min, mg/kg/hr, mg/hr, ng/kg/min, g/hr, mEq/hr, Million units/hr, units/min, units/hr, units/kg/hr, units/kg/min, mmol/min, mmol/hr. *Refurbished *1-Year Warranty
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Intravenous Ascorbic Acid: protocol for its application and use - 0 views
www.riordanclinic.org/...89022715.pdf
IVC vitamin C IV vitamin C intravenous infusion rate vitamin C infusion rate IV infusion rate
shared by Nathan Goodyear on 29 May 13
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Pregnancy Outcome After Intralipid Infusion Among Women Experiencing Recurrent Pregnanc... - 0 views
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The Role of Post-Exercise Nutrient Administration on Muscle Protein Synthesis and Glyco... - 0 views
www.ncbi.nlm.nih.gov/...PMC3761704
exercise athlete athletes recovery exercise recovery training protein carbohydrates glycogen muscle
shared by Nathan Goodyear on 10 Feb 16
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Free form amino acid ingestion acts similarly to whey by displaying a rapid and strong increase in aminoacidemia
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it appears that protein synthesis rapidly increases for up to two hours after amino acid administration
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The intervention of dietary protein or amino acid supplementation in conjunction with resistance training has proven to effectively increase protein synthesis rates
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291% increase in protein synthesis following the exercise bout, while protein degradation remained unchanged from baseline quantities
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it has been established that post-exercise EAA supplementation stimulates protein synthesis, in conjunction with a positive protein balance, comparable to that of intravenous infusion of amino acids
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Casein and whey protein ingestion yielded similar values of net positive protein balance, and thus an overall increase in protein synthesis
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A later analysis revealed that soy protein increased protein synthesis in rats similar to that of whey after a treadmill exercise protocol
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A human trial, however, concluded that milk proteins (caseins and whey) in comparison to soy promoted greater muscle protein accretion when they were ingested after regular resistance training
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Whey hydrolysate ingested after a resistance exercise bout acutely stimulated mixed muscle protein synthesis 31% greater than soy
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adequate amount of protein (20 g) is ingested (Tipton et al., 2009) immediately before or after a resistance exercise bout
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slow phase, which can last up to several hours if carbohydrate availability is high and insulin levels remain elevated